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Rams vs. Cardinals prediction, prop bets Week 10: LA’s rushing duo keeps Arizona winless at home

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All eyes will be on Sean McVay and the Rams’ redesigned offense as they look to avenge an upset loss to the Cardinals from earlier in the season on Sunday.

The Rams are 9.5-point road favorites, and for the first time in nearly two seasons, Matthew Stafford will miss both members of his star-studded receiving tandem of Puka Nacua and Davante Adams. 

Then there’s the dubious and head-scratching fact that the Cardinals have lost 10 straight games at State Farm Stadium. 

With the Rams’ receiving corps out due to injury and uncertainty surrounding rookie Carson Beck under center, the total has been juiced down from its opening line of 47.5 to 39.5 at most books. 

Rams vs. Cardinals prediction, best prop bets

Now that Jacoby Brissett is a Raven and Gardner Minshew is on IR, Beck will make his NFL debut; what better way to welcome him than with a front seven led by Myles Garrett and Aaron Donald?

Leading target Trey McBride remains a safety net for Beck, but the bad news is that the Cardinals’ offensive line has surrendered 3 or more sacks in three straight games. 

Garrett is coming off a hat trick in Week 9 against the Commanders, and the once-troubled Rams defense now ranks sixth in DVOA, including fourth against the run and eighth against the pass.

Los Angeles Rams defensive tackle Aaron Donald (99) greets defensive end Myles Garrett (95) during an NFL game in Landover, Md., Sunday, Nov. 8, 2026. AP Photo/Stephanie Scarbrough

Arizona may try to establish the run and control time of possession, as it did in the first meeting. But with a first-year starter getting his debut reps behind a banged-up offensive line, that approach is unlikely to be as successful as it was last time. 

Instead, I think the Rams will be better at establishing the run behind their running back duo of Kyren Williams and Blake Corum. 

McVay has gradually cut back Williams’ workload, while Corum has been just as productive—or even more so—without much attention. 

Either way, the Rams will likely get shorter field opportunities at the expense of takeaways. 

In the Week 6 loss, Williams played 72 percent of the snaps, but Corum found the end zone on a 15-yard reception on 28 percent of snaps.


Betting on the NFL?


There are plenty of ways to target them, from betting on both to score a touchdown to taking the over on their rushing lines against a Cardinals defense that allows opposing backs 161.3 rushing yards at home.

I’ll parlay Williams to score and Corum to go over on his short 6.5-yard receiving prop.

The Play: SGP (+210, Novig) – Kyren Williams to score a touchdown + Blake Corum 7 or more receiving yards


Why Trust New York Post Betting

Mike Turay is a sports journalist and editor who closely follows the NBA, NFL, college sports and UFC. He has demonstrated expertise in both NBA and NFL player prop bets for nearly three years. Mike is also highly knowledgeable about the sportsbook offer landscape, frequently trying and reviewing the latest apps and sites.

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