A total of 131 cases were recorded nationally between 2000 and 2025, 17 of which were fatal, the CDC’s database says
The US Centers for Disease Control and Prevention (CDC) has updated its estimate of annual human plague infections in the country, lowering it from seven to five.
On Wednesday, the CDC amended its Plague Maps and Statistics page, which now states: “An average of five human plague cases are reported each year in the United States.” The previous version, dated March 2025, cited seven cases annually, although its own year-by-year data already showed an average of approximately five.
The agency has not provided an explanation for the revision.
According to the CDC’s current data, there were a total of 131 plague cases across the US between 2000 and 2025, 17 of which were lethal. The highest number of cases dates back to 2006 (17) and 2015 (16). In the latter case, four people died – the highest annual death toll during the period.
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