Christina Applegate rose to fame as ‘Kelly Bundy’ on Married… with Children and went on to star in hits like Anchorman, Samantha Who?, and Netflix’s Dead to Me, winning an Emmy along the way. Her career was interrupted by major health battles, including a breast cancer diagnosis in 2008 that led to a double mastectomy and, in 2021, multiple sclerosis. Since then, she has stepped back from on-screen acting and become a candid advocate for chronic illness.
Although Christina has maintained a distance from the screen for a long time, she has frequently spoken about her battle with MS on various occasions. One of those conversations happened with PEOPLE around two years ago, in 2024. In the same interview, she even responded to the claims that she used Ozempic.
Christina Applegate revealed the truth behind her weight loss
Back in March 2024, Christina Applegate had spoken candidly about living with multiple sclerosis after she was diagnosed with the disease in 2021. She appeared for an interview with PEOPLE at that time with Jamie-Lynn Sigler, who was also battling the same health problem. Notably, the duo reflected on how unpredictable life with the disease had been.
Applegate had revealed that her body had gone through major changes. She said the combination of steroid treatment and reduced movement had caused her to put on about 45 pounds in the beginning, followed by a loss of nearly 30 pounds.
Christina firmly clarified that her weight loss was not due to Ozempic. She recalled that after her surprise appearance at the Emmy Awards in January 2024, where she had joked on stage that her body was not a result of the drug, speculation had grown about whether she had used it. She stated that was not the case and attributed the drop in weight to constant vomiting caused by her health issues.
She also shared that she had been hospitalized several times when doctors were unable to pinpoint the problem, describing severe digestive issues that brought intense pain and nausea. The actress even opened up about dealing with bladder control problems that required her to wear protective undergarments every day, adding that she disliked their decorative floral prints.
Despite the hardships, both women had found moments of dark humor. Applegate had joked about the benefit of easy parking, while Sigler had said they had earned their handicap placards and would not give them up even if a cure was discovered.
Christina Applegate has been dealing with multiple health issues for a long time
Christina Applegate has faced serious health challenges over nearly two decades. In 2008, at 36, she was diagnosed with early-stage breast cancer during a routine MRI. Because she had dense breast tissue and her mother had fought breast cancer twice, she had started screening early.
Further testing showed she carried the BRCA1 gene mutation, which greatly raises the risk of both breast and ovarian cancer. Although cancer was found in only one breast, she chose to have a double mastectomy. She also had her ovaries and fallopian tubes removed as a preventive measure in 2017. She later started Right Action for Women to help high-risk women afford screening.
Christina Applegate’s second major battle began in early 2021 while filming the final season of Dead to Me. She first noticed tingling in her toes and lost balance during a dance scene. By summer, she had to be taken to set in a wheelchair, and production was paused for five months. She announced in August 2021 that she had multiple sclerosis.
Since then, she has spoken openly about chronic pain, limited mobility, using a cane, and spending much of her day in bed. She has said she has faced dozens of hospital stays, severe stomach and bladder issues, and now focuses on advocacy through her podcast MeSsy and her memoir You With The Sad Eyes.
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